Species-specific temperature sensitivity of TRPA1
نویسندگان
چکیده
منابع مشابه
Species-specific temperature sensitivity of TRPA1
Transient receptor potential ankyrin 1 (TRPA1) is a polymodal ion channel sensitive to temperature and chemical stimuli. The importance of temperature and aversive chemical detection for survival has driven the evolutionary diversity of TRPA1 sensitivity. This diversity can be observed in the various roles of TRPA1 in different species, where it is proposed to act as a temperature-insensitive c...
متن کاملTRPA1 channels: chemical and temperature sensitivity.
Transient receptor potential ankyrin 1 (TRPA1) is a polymodal excitatory ion channel found in sensory neurons of different organisms, ranging from worms to humans. Since its discovery as an uncharacterized transmembrane protein in human fibroblasts, TRPA1 has become one of the most intensively studied ion channels. Its function has been linked to regulation of heat and cold perception, mechanos...
متن کاملSpecies differences and molecular determinant of TRPA1 cold sensitivity
TRPA1 is an ion channel and has been proposed as a thermosensor across species. In invertebrate and ancestral vertebrates such as fly, mosquito, frog, lizard and snakes, TRPA1 serves as a heat receptor, a sensory input utilized for heat avoidance or infrared detection. However, in mammals, whether TRPA1 is a receptor for noxious cold is highly controversial, as channel activation by cold was ob...
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provided a comprehensive review on the recent progress and remaining puzzles. Ample evidence suggests that the sensory function of TRPA1 is evolutionarily conserved. This notion is further supported by the fact that TRPA1 from several mammalian species (human, rat, and mouse) is activated by common ligands (a plethora of electrophylus) through a common mechanism (covalent modification). However...
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Pain is a harmful sensation that arises from noxious stimuli. Transient receptor potential ankyrin 1 (TRPA1) is one target for studying pain mechanisms. TRPA1 is activated by various stimuli such as noxious cold, pungent natural products and environmental irritants. Since TRPA1 is an attractive target for pain therapy, a few TRPA1 antagonists have been developed and some function as analgesic a...
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ژورنال
عنوان ژورنال: Temperature
سال: 2015
ISSN: 2332-8940,2332-8959
DOI: 10.1080/23328940.2014.1000702